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through each step of getting your Genentech medicine.
Frequently Asked Questions
About ZELBORAF Access Solutions
What is ZELBORAF Access Solutions?
ZELBORAF Access Solutions is a resource for people who take a
Genentech medicine. We connect you to the medicine you need.
I Am Concerned About Paying for ZELBORAF
My co-pays for ZELBORAF are too high. How can you help me?
There may be options to help you get the Genentech medicine your doctor has prescribed. ZELBORAF Access Solutions can refer you to patient assistance options.
Where can I find information about the Genentech® Access to Care Foundation (GATCF)?
Getting My Medicine
Can I pick up my Genentech medicine from my local pharmacy?
You can’t get your Genentech medicine from your local pharmacy. Instead, it will come to you from a specialty pharmacy.
Your specialty pharmacy is different from your regular mail-order pharmacy. It handles drugs like ZELBORAF.
When we check your coverage, we also refer you to a specialty pharmacy your health insurance plan will cover.
How long will it take to get my medicine?
You might not be able to get your Genentech medicine right away. First, your doctor’s office or specialty pharmacy will have to check to make sure your health insurance plan covers your medicine. This is called a “benefits investigation.” They also might have to send some more information before your plan covers your medicine. This is called a “prior authorization.”
Enrolling in ZELBORAF Access Solutions
How do I enroll in ZELBORAF Access Solutions?
- You fill out a form called the PAN.
- Your doctor fills out a form called the Prescriber Service Form. You do not have to fill out anything on this form.
- Your doctor sends both of these forms to ZELBORAF Access Solutions.
There are 2 ways to fill out the PAN form:
- You can fill out the form online
- You can download and print it to fill out a paper copy
Why do I need to sign the PAN form?
The PAN form lets us discuss your health information with your doctor
and your health insurance plan. We can’t work with you without a
I submitted the PAN online or gave the signed PAN to my doctor. Is there anything else I need to do to enroll?
You do not need to do anything else, but your doctor does. He or she needs to submit a form called the Prescriber Service Form. This form tells us your doctor wants to treat you with ZELBORAF. Make sure your doctor has sent us the Prescriber Service Form so you get help from us.
You do not need to fill out anything on the Prescriber Service Form.
My Health Plan Denied Coverage for ZELBORAF
My health insurance plan will not cover ZELBORAF. What do I do?
If your health insurance plan will not cover your Genentech medicine,
you and your doctor's office can file an appeal. Contact your doctor
to ask if you should file an appeal.
We have resources to help you and your doctor file an appeal.
Does ZELBORAF Access Solutions send the appeal to my health insurance plan?
We have resources to help you and your doctor file an appeal. You or
your doctor’s office has to file the appeal directly with your health
How long does an appeal take?
This depends on your health insurance plan. You should ask your plan directly about its process. Sometimes the appeals process is quick. However, it can take several months if you have to appeal several times.
My Insurance Might Change
I am enrolled in ZELBORAF Access Solutions and my health insurance plan has changed. What do I do next?
If your insurance changes while you’re taking your Genentech
medicine, call us. We can help you understand your new coverage.
I no longer have a health insurance plan. What should I do?
The Genentech Patient Foundation gives free Genentech medicine to
people who don't have insurance coverage or who have financial
concerns and to people who meet certain income criteria.
It is your and your doctor's responsibility to complete and submit
all required paperwork to your health insurance plan. Genentech
cannot guarantee your plan will cover any treatments.
PAN=Patient Authorization and Notice of Request
for Transmission of Health Information to Genentech Access Solutions
and Genentech® Access to Care Foundation.
Important Safety Information & Indication
What it Treats
What is ZELBORAF APPROVED FOR?
ZELBORAF is a prescription medicine used to treat a type of skin cancer called melanoma that has spread to other parts of the body or cannot be removed by surgery, and that has a certain type of abnormal “BRAF” gene.
ZELBORAF is not used to treat melanoma with a normal BRAF gene.
Your healthcare provider will perform a test to make sure ZELBORAF is right for you.
ZELBORAF is a prescription medicine used to treat a type of blood cell cancer called Erdheim–Chester disease (ECD), that can affect body tissues and organs, and that has a certain type of abnormal “BRAF” gene.
It is not known if ZELBORAF is safe and effective in children under 18 years of age.
Important Safety Information
What is the most important information I should know about ZELBORAF?
ZELBORAF can cause serious side effects, including:
- Risk of new cancers. ZELBORAF may cause certain types of skin cancer called cutaneous squamous cell carcinoma (cuSCC) and keratoacanthoma. New melanoma lesions have occurred in people who take ZELBORAF. ZELBORAF may also cause another type of cancer called non-cutaneous squamous cell carcinoma (non-cuSCC). Talk with your healthcare provider about your risk for these cancers.
Check your skin and tell your healthcare provider right away about any skin changes, including:
- A new wart
- A skin sore or reddish bump that bleeds or does not heal
- A change in size or color of a mole
Your healthcare provider should check your skin before you start taking ZELBORAF, and every 2 months during treatment with ZELBORAF, to look for any new skin cancers. Your healthcare provider may continue to check your skin for 6 months after you stop taking ZELBORAF.
Your healthcare provider should also check for cancers that may not occur on the skin. Tell your healthcare provider about any new symptoms that you get while taking ZELBORAF.
Other blood cancers have happened in some people with Erdheim-Chester Disease (ECD) including those who take ZELBORAF. If you have other blood cancers and take ZELBORAF for ECD, your healthcare provider will monitor your blood cancer through routine blood tests.
Before you take ZELBORAF, tell your healthcare provider about all of your medical conditions, including if you:
- Have any heart problems, including a condition called long QT syndrome
- Have liver or kidney problems
- Have had or are planning to receive radiation therapy
- Have been told that you have low blood levels of potassium, calcium, or magnesium
- Are pregnant or plan to become pregnant. ZELBORAF can harm your unborn baby.
- Females who are able to become pregnant should use effective birth control during treatment with ZELBORAF and for 2 weeks after the final dose of ZELBORAF
- Talk to your healthcare provider about birth control methods that may be right for you
- Tell your healthcare provider right away if you become pregnant during treatment with ZELBORAF
- Are breastfeeding or plan to breastfeed. It is not known if ZELBORAF passes into your breast milk. Do not breastfeed during treatment with ZELBORAF and for 2 weeks after the final dose of ZELBORAF. Talk to your healthcare provider about the best way to feed your baby during this time.
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What should I avoid while taking ZELBORAF?
Avoid sunlight during treatment with ZELBORAF. ZELBORAF can make your skin sensitive to sunlight. You may burn more easily and get severe sunburns. To help protect against sunburn:
- When you go outside, wear clothes that protect your skin, including your head, face, hands, arms, and legs.
- Use lip balm and a broad-spectrum sunscreen with SPF 30 or higher.
What are the possible side effects of ZELBORAF?
- Allergic reactions can happen while taking your ZELBORAF, and can be severe. Stop taking ZELBORAF and get medical help right away if you get any of these symptoms of an allergic reaction:
- Rash or redness all over your body
- Trouble breathing or swallowing
- Swelling of the face, lips, or tongue
- Throat tightness or hoarseness
- Feel faint
- Fast heartbeat
- Severe skin reactions. Stop taking ZELBORAF and call your healthcare provider right away if you get a skin rash with any of the following symptoms, because you may have a severe skin reaction:
- Blisters on your skin
- Blisters or sores in your mouth
- Peeling of your skin
- Redness or swelling of your face, hands, or soles of your feet
- Changes in the electrical activity of your heart called QT prolongation. QT prolongation can cause irregular heartbeats that can be life-threatening. Your healthcare provider should do tests before you start taking ZELBORAF and during your treatment with ZELBORAF to check the electrical activity of your heart and your and your body salts (electrolytes). Tell your healthcare provider right away if you feel faint, lightheaded, dizzy, or feel your heart beating irregularly or fast while taking ZELBORAF. These may be symptoms related to QT prolongation.
- Liver injury. Your healthcare provider should do blood tests to check your liver function before you start taking ZELBORAF and during treatment. Tell your healthcare provider right away if you get any of these symptoms of a liver problem during treatment:
- Yellowing of your skin or the white part of your eyes
- Dark or brown (tea color) urine
- Nausea or vomiting
- Loss of appetite
- Pain on the right side of your stomach
- Eye problems. Tell your healthcare provider right away if you get any of these symptoms during treatment with ZELBORAF:
- Eye pain, swelling, or redness
- Blurred vision or other vision changes
- Worsening side effects from radiation treatment that can sometimes be severe or lead to death. Tell your healthcare provider if you have had or are planning to receive radiation therapy.
- Kidney injury. Your healthcare provider should do blood tests to check your kidney function before you start taking ZELBORAF and during treatment.
- Connective tissue disorders. Tell your healthcare provider if you develop an unusual thickening of the palms of your hands along with tightening of the fingers inward or any unusual thickening of the soles of your feet which may be painful.
The most common side effects of ZELBORAF in melanoma include:
- Joint pain
- Rash (see “Severe skin reactions” above)
- Hair loss
- Sunburn or sun sensitivity
The most common side effects of ZELBORAF in Erdheim-Chester Disease include:
- Joint pain
- Hair loss
- QT prolongation (see “Changes in the electrical activity of your heart called QT prolongation” above)
These are not all of the possible side effects of ZELBORAF. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.
Please see accompanying Full Prescribing Information and Medication Guide for additional Important Safety Information.